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Is Parkinson's really a disease? Reframing it as a phenotype of aging.

Parkinsonism & related disorders - 1 Aug 2026

Dashtipour Khashayar

Abstract excerpt

The boundary between aging and neurodegenerative disorders remains unresolved, and emerging evidence challenges this dichotomy. Parkinson's disease (PD) has traditionally been defined as a neurodegenerative disease with motor and non-motor manifestations. It was not until two decades ago that clinical and research studies shed light on PD heterogeneity at the clinical, pathological, cellular, and genetic levels....

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PMID: 42276868
DOI: 10.1016/j.parkreldis.2026.108387

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