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Article

The insulin-sensitivity sulphonylurea receptor variant is associated with thyrotoxic paralysis.

Journal of molecular endocrinology - 1 Oct 2014

Rolim Ana Luiza R, Lindsey Susan C, Kunii Ilda S, Crispim Felipe, Moisés Regina Célia M S, Maciel Rui M B, Dias-da-Silva Magnus R

Abstract excerpt

Thyrotoxicosis is the most common cause of the acquired flaccid muscle paralysis in adults called thyrotoxic periodic paralysis (TPP) and is characterised by transient hypokalaemia and hypophosphataemia under high thyroid hormone levels that is frequently precipitated by carbohydrate load. The sulphonylurea receptor 1 (SUR1 (ABCC8)) is an essential regulatory subunit of the β-cell ATP-sensitive K(+) channel that...

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Identifiers

PMID: 25143473
DOI: 10.1530/JME-14-0083

Genes

ABCC8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The insulin-sensitivity sulphonylurea receptor variant is associated with thyrotoxic paralysis.PMID 25143473Read ↗

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