Association between ABCC8 Ala1369Ser Polymorphism (rs757110 T/G) and Type 2 Diabetes Risk in an Iranian Population: A Case-Control Study.

doi:10.2174/1871530320666200713091827

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Association between ABCC8 Ala1369Ser Polymorphism (rs757110 T/G) and Type 2 Diabetes Risk in an Iranian Population: A Case-Control Study.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2021

Bakhtiyari Amin, Haghani Karimeh, Bakhtiyari Salar, Zaimy Mohammad A, Noori-Zadeh Ali, Gheysarzadeh Ali, Darabi Shahram, Seidkhani-Nahal Ali, Amraei Mansour, Alipourfard Iraj

Abstract excerpt

OBJECTIVE: Glucose metabolism increases ATP/ADP ratio within the β-cells and causes ATP-sensitive K+ (KATP) channel closure and consequently insulin secretion. The enhanced activity of the channel may be a mechanism contributing to the reduced first-phase of insulin secretion observed in T2DM. There is no study to date in the Kurdish ethnic group regarding the relationship between SNP Ala1369Ser (rs757110 T/G) of...

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PMID: 32660410
DOI: 10.2174/1871530320666200713091827

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