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Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence

1 Dec 2015

Abstract excerpt

Cancer cells can undergo stress-induced premature senescence, which is considered to be a desirable outcome of anticancer treatment. However, the escape from senescence and cancer cell repopulation give rise to some doubts concerning the effectiveness of the senescence-induced anticancer therapy. Similarly, it is postulated that polyploidization of cancer cells is connected with disease relapse. We postulate that...

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PMID: 26696370
DOI: 10.1016/j.neo.2015.11.008

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