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A Vps21 endocytic module regulates autophagy

21 Aug 2014

Abstract excerpt

In autophagy, the double-membrane autophagosome delivers cellular components for their degradation in the lysosome. The conserved Ypt/Rab GTPases regulate all cellular trafficking pathways, including autophagy. These GTPases function in modules that include guanine-nucleotide exchange factor (GEF) activators and downstream effectors. Rab7 and its yeast homologue, Ypt7, in the context of such a module, regulate...

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PMID: 25143401
DOI: 10.1091/mbc.e14-04-0917

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