Article
Double heterozygosity for mutations in BRCA1 and BRCA2 in German breast cancer patients: implications on test strategies and clinical management.
Breast cancer research and treatment - 1 Aug 2012
Heidemann Simone, Fischer Christine, Engel Christoph, Fischer Barbara, Harder Lana, Schlegelberger Brigitte, Niederacher Dieter, Goecke Timm O, Doelken Sandra C, Dikow Nicola, Jonat Walter, Morlot Susanne, Schmutzler Rita C, Arnold Norbert K
Abstract excerpt
Double heterozygosity for disease-causing BRCA1 and BRCA2 mutations is a very rare condition in most populations. Here we describe genetic and clinical data of eight female double heterozygotes (DH) for BRCA1 and BRCA2 mutations found in a cohort of 8162 German breast/ovarian cancer families and compare it with the data of their single heterozygous relatives and of the index patients of the German Consortium for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.