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Article

Timing of risk reducing mastectomy in breast cancer patients carrying a BRCA1/2 mutation: retrospective data from the Dutch HEBON study.

Familial cancer - 1 Sept 2015

Wevers M R, Schmidt M K, Engelhardt E G, Verhoef S, Hooning M J, Kriege M, Seynaeve C, Collée M, van Asperen C J, Tollenaar R A E M, Koppert L B, Witkamp A J, Rutgers E J T, Aaronson N K, Rookus M A, Ausems M G E M

Abstract excerpt

It is expected that rapid genetic counseling and testing (RGCT) will lead to increasing numbers of breast cancer (BC) patients knowing their BRCA1/2 carrier status before primary surgery. Considering the potential impact of knowing one's status on uptake and timing of risk-reducing contralateral mastectomy (RRCM), we aimed to evaluate trends over time in RRCM, and differences between carriers identified either...

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Identifiers

PMID: 25700605
DOI: 10.1007/s10689-015-9788-x
PMCID: PMC4559099

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BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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