Article
Prevalence of BRCA1 mutations among 403 women with triple-negative breast cancer: implications for genetic screening selection criteria: a Hellenic Cooperative Oncology Group Study.
Breast cancer research and treatment - 1 Jul 2012
Fostira Florentia, Tsitlaidou Marianthi, Papadimitriou Christos, Pertesi Maroulio, Timotheadou Eleni, Stavropoulou Alexandra V, Glentis Stavros, Bournakis Evangelos, Bobos Mattheos, Pectasides Dimitrios, Papakostas Pavlos, Pentheroudakis George, Gogas Helen, Skarlos Pantelis, Samantas Epaminontas, Bafaloukos Dimitrios, Kosmidis Paris A, Koutras Angelos, Yannoukakos Drakoulis, Konstantopoulou Irene, Fountzilas George
Abstract excerpt
In spite the close association of the triple-negative breast cancer immunophenotype with hereditary breast cancers and the BRCA1 pathway, there is a lack of population studies that determine the frequency of BRCA1 mutations among triple-negative breast cancer patients. To address this, we have screened a large sample of 403 women diagnosed with triple-negative invasive breast cancer, independently of their age or...
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