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Contribution of BRCA1 and BRCA2 germ-line mutations to the incidence of breast cancer in young women: results from a prospective population-based study in France.

Genes, chromosomes & cancer - 1 Aug 2005

Bonadona Valerie, Sinilnikova Olga M, Chopin Sandrine, Antoniou Antonis C, Mignotte Hervé, Mathevet Patrice, Brémond Alain, Martin Alain, Bobin Jean-Yves, Romestaing Pascale, Raudrant Daniel, Rudigoz René-Charles, Léoné Mélanie, Chauvin Franck, Easton Douglas F, Lenoir Gilbert M, Lasset Christine

Abstract excerpt

The prevalence of BRCA1/2 germ-line mutations was assessed in a prospective population-based series of early-onset breast cancer (BC) patients in France, and the usefulness of a clinical assessment of hereditary BC risk, based on multiple criteria including pedigree structure, was evaluated. Through the Rhone region BC registry, 232 women diagnosed with BC before 46 years of age were included. They were tested...

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Identifiers

PMID: 15887246
DOI: 10.1002/gcc.20199

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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