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Article

Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons.

Neurobiology of disease - 1 Nov 2014

Quintanilla Rodrigo A, von Bernhardi Rommy, Godoy Juan A, Inestrosa Nibaldo C, Johnson Gail V W

Abstract excerpt

Tau phosphorylated at the PHF-1 epitope (S396/S404) is likely involved in the pathogenesis of Alzheimer's disease (AD). However, the molecular mechanisms by which tau phosphorylated at these sites negatively impacts neuronal functions are still under scrutiny. Previously, we showed that expression of tau truncated at D421 enhances mitochondrial dysfunction induced by Aβ in cortical neurons. To extend these...

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Identifiers

PMID: 25134729
DOI: 10.1016/j.nbd.2014.08.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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