Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Worsening of Huntington disease phenotype in CB1 receptor knockout mice.

Neurobiology of disease - 1 Jun 2011

Mievis Stéphane, Blum David, Ledent Catherine

Abstract excerpt

Huntington's disease (HD) is a progressive neurodegenerative genetic disorder which leads to motor, cognitive and psychiatric disturbances. The primary neuropathological hallmark is atrophy of the striatum. Cannabinoid CB1 receptors (CB1Rs) are particularly enriched in the striatum and previous works indicate their early loss of expression in HD, even before symptom occurrence. However, pathophysiological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analysis of Variance
Share to Corpus Striatum
Share to Huntington Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Motor Activity

Share to Nitro Compounds

Share to Propionates

Share to Receptor, Cannabinoid, CB1

Share to Rotarod Performance Test

Source

Identifiers

PMID: 21406230
DOI: 10.1016/j.nbd.2011.03.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Worsening of Huntington disease phenotype in CB1 receptor knockout mice.PMID 21406230Read ↗

Delayed onset of huntington′s disease in mice in an enriched environment correlates with delayed loss of cannabinoid CB1 receptorsSemantic proximity Read ↗

Widespread Decrease of Type 1 Cannabinoid Receptor Availability in Huntington Disease In VivoSemantic proximity Read ↗

Genetic rescue of CB1 receptors on medium spiny neurons prevents loss of excitatory striatal synapses but not motor impairment in HD mice.Semantic proximity Read ↗

An enquiry to the role of CB1 receptors in neurodegenerationSemantic proximity Read ↗

Genetic deletion of CB1 cannabinoid receptors exacerbates the Alzheimer-like symptoms in a transgenic animal modelSemantic proximity Read ↗

Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic miceSemantic proximity Read ↗

Overview of Huntington's Disease Models: Neuropathological, Molecular, and Behavioral Differences.Semantic proximity Read ↗

Targeting the cannabinoid CB2 receptor to attenuate the progression of motor deficits in LRRK2-transgenic mice.Semantic proximity Read ↗

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 miceSemantic proximity Read ↗

Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic miceSemantic proximity Read ↗

Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington’s disease miceSemantic proximity Read ↗

Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.