Too much of a good thing: immunodeficiency due to hyperactive PI3K signaling.

Abstract excerpt

Primary immune deficiency diseases arise due to heritable defects that often involve signaling molecules required for immune cell function. Typically, these genetic defects cause loss of gene function, resulting in primary immune deficiencies such as severe combined immune deficiency (SCID) and X-linked agammaglobulinemia (XLA); however, gain-of-function mutations may also promote immune deficiency. In this issue...

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• Share to Class Ia Phosphatidylinositol 3-Kinase
• Share to Immunologic Deficiency Syndromes