Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Malignant effects of multiple rare variants in sarcomere genes on the prognosis of patients with hypertrophic cardiomyopathy.

European journal of heart failure - 1 Sept 2014

Wang Jizheng, Wang Yilu, Zou Yubao, Sun Kai, Wang Zhimin, Ding Hu, Yuan Jinqing, Wei Wei, Hou Qing, Wang Hu, Liu Xuan, Zhang Hongju, Ji Yun, Zhou Xianliang, Sharma Ravi K, Wang Daowen, Ahmad Ferhaan, Hui Rutai, Song Lei

Abstract excerpt

AIMS: Although genetic testing has been recommended in patients with hypertrophic cardiomyopathy (HCM) in current clinical practice, its utility in prognostic prediction remains to be ascertained. We assessed the dosage effect of rare variants in sarcomere genes on the long-term outcomes of HCM. METHODS AND RESULTS: A total of 529 unrelated HCM patients were prospectively recruited and followed for 4.7 ± 3.2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy, Hypertrophic
Share to China

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Follow-Up Studies

Share to Genetic Testing

Share to Sarcomeres

Share to Survival Rate

Share to Time Factors

Source

Identifiers

PMID: 25132132
DOI: 10.1002/ejhf.144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Malignant effects of multiple rare variants in sarcomere genes on the prognosis of patients with hypertrophic cardiomyopathy.PMID 25132132Read ↗

Phenotypic Expression and Outcomes in Individuals With Rare Genetic Variants of Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

Outcomes and phenotypic expression of rare variants in hypertrophic cardiomyopathy genes amongst UK Biobank participantsSemantic proximity Read ↗

Low Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

Characteristics and outcomes associated with sarcomere mutations in patients with hypertrophic cardiomyopathy: A systematic review and meta-analysis.Semantic proximity Read ↗

Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity.Semantic proximity Read ↗

What Causes Hypertrophic Cardiomyopathy?Semantic proximity Read ↗

Cardiovascular Health and Outcomes in Carriers With Genetic Variants of Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts.Semantic proximity Read ↗

Genetic diversity and molecular mechanisms in hypertrophic cardiomyopathy: toward personalized therapy.Semantic proximity Read ↗

Sarcomere Variants of Uncertain Significance identify an Intermediate Clinical Risk Profile in Hypertrophic CardiomyopathySemantic proximity Read ↗

Genetics of hypertrophic cardiomyopathy: established and emerging implications for clinical practice.Semantic proximity Read ↗

Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.