Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes.

European heart journal - 7 Dec 2017

Walsh Roddy, Buchan Rachel, Wilk Alicja, John Shibu, Felkin Leanne E, Thomson Kate L, Chiaw Tang Hak, Loong Calvin Chin Woon, Pua Chee Jian, Raphael Claire, Prasad Sanjay, Barton Paul J, Funke Birgit, Watkins Hugh, Ware James S, Cook Stuart A

Abstract excerpt

AIM: Hypertrophic cardiomyopathy (HCM) exhibits genetic heterogeneity that is dominated by variation in eight sarcomeric genes. Genetic variation in a large number of non-sarcomeric genes has also been implicated in HCM but not formally assessed. Here we used very large case and control cohorts to determine the extent to which variation in non-sarcomeric genes contributes to HCM. METHODS AND RESULTS: We sequenced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy and Myosin Studies
Share to Cardiomyopathy, Hypertrophic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiovascular Effects of Exercise

Share to Case-Control Studies

Share to Genetic Variation

Share to Mutation

Share to Sarcomeres

Source

Open in PubMed Open full text

Identifiers

PMID: 28082330
DOI: 10.1093/eurheartj/ehw603
PMCID: PMC5837460

Genes

ACTN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes.PMID 28082330Read ↗

Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity.Semantic proximity Read ↗

Minor hypertrophic cardiomyopathy genes, major insights into the genetics of cardiomyopathies.Semantic proximity Read ↗

Genetic, genotype and imaging studies of hypertrophic cardiomyopathySemantic proximity Read ↗

Genetics of hypertrophic cardiomyopathy: established and emerging implications for clinical practice.Semantic proximity Read ↗

Contemporary Insights Into the Genetics of Hypertrophic Cardiomyopathy: Toward a New Era in Clinical Testing?Semantic proximity Read ↗

What Causes Hypertrophic Cardiomyopathy?Semantic proximity Read ↗

Analysis of 51 proposed hypertrophic cardiomyopathy genes from genome sequencing data in sarcomere negative cases has negligible diagnostic yieldSemantic proximity Read ↗

Nonfamilial Hypertrophic Cardiomyopathy: Prevalence, Natural History, and Clinical Implications.Semantic proximity Read ↗

Low Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

A Potential Oligogenic Etiology of Hypertrophic Cardiomyopathy: A Classic Single-Gene Disorder.Semantic proximity Read ↗

Hypertrophic Cardiomyopathy: Genetic Testing and Risk Stratification.Semantic proximity Read ↗

Evaluation of polygenic score for hypertrophic cardiomyopathy in the general population and across clinical settingsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.