Article

Sarcomere Variants of Uncertain Significance identify an Intermediate Clinical Risk Profile in Hypertrophic Cardiomyopathy

2026-03-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The clinical significance of sarcomere variants of uncertain significance (VUS) in hypertrophic cardiomyopathy (HCM) remains unclear, and VUS are currently regarded as clinically non-actionable despite their increasing prevalence. This study aimed to evaluate genotype–phenotype and genotype–outcome associations according to variant pathogenicity in patients with HCM, with a...

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Literature Corpus work: da3db840-e747-52e7-9cc9-4f6a78975ecd
DOI: 10.64898/2026.03.17.26348662

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