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Article

Genetic diversity and molecular mechanisms in hypertrophic cardiomyopathy: toward personalized therapy.

American journal of physiology. Heart and circulatory physiology - 1 Apr 2026

Marwaha Komal, Mody Behram, Holland Nathan, Lane Mariela, Shoemake Brittany D, Singh Namrata, Mody Freny Vaghaiwalla

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac muscle disorder, yet contemporary genomic and mechanistic research still lacks a cohesive model explaining how diverse genetic architectures give rise to heterogeneous phenotypes. This review synthesizes advances across sarcomeric and nonsarcomeric mutations, including intermediate-effect variants, polygenic modifiers, and ancestry-dependent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41604255
DOI: 10.1152/ajpheart.00500.2025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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