Article
Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting.
Hepatology (Baltimore, Md.) - 1 Dec 2014
Gu Qilin, Yang Xiaojie, Lin Li, Li Shaoyang, Li Qing, Zhong Shan, Peng Jinrong, Cui Zongbin
Abstract excerpt
UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder caused by abnormal lipid metabolisms, such as reduced hepatic fatty acid oxidation (FAO), but intracellular control of FAO under physio- and pathological conditions remains largely undefined. Here, we demonstrate that deprivation of Slc7a3a leads to hepatic steatosis in fasted zebrafish as a result of defects in...
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