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The X Gene of Adeno-Associated Virus 2 (AAV2) Is Involved in Viral DNA Replication

15 Aug 2014

Abstract excerpt

Adeno-associated virus (AAV) (type 2) is a popular human gene therapy vector with a long active transgene expression period and no reported vector-induced adverse reactions. Yet the basic molecular biology of this virus has not been fully addressed. One potential gene at the far 3' end of the AAV2 genome, previously referred to as X (nt 3929 to 4393), overlapping the 3' end of the cap gene, has never been...

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PMID: 25127256
DOI: 10.1371/journal.pone.0104596

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