Article
Mutations in POLE and survival of colorectal cancer patients--link to disease stage and treatment.
Cancer medicine - 1 Dec 2014
Stenzinger Albrecht, Pfarr Nicole, Endris Volker, Penzel Roland, Jansen Lina, Wolf Thomas, Herpel Esther, Warth Arne, Klauschen Frederick, Kloor Matthias, Roth Wilfried, Bläker Hendrik, Chang-Claude Jenny, Brenner Hermann, Hoffmeister Michael, Weichert Wilko
Abstract excerpt
Recent molecular profiling studies reported a new class of ultramutated colorectal cancers (CRCs), which are caused by exonuclease domain mutations (EDMs) in DNA polymerase ϵ (POLE). Data on the clinical implications of these findings as to whether these mutations define a unique CRC entity with distinct clinical outcome are lacking. We performed Sanger sequencing of the POLE exonuclease domain in 431...
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