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Article

Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer.

Journal for immunotherapy of cancer - 1 Aug 2020

Mo Shaobo, Ma Xiaoji, Li Yaqi, Zhang Long, Hou Ting, Han-Zhang Han, Qian Juanjuan, Cai Sanjun, Huang Dan, Peng Junjie

Abstract excerpt

Previous studies found patients with POLE exonuclease domain mutations (EDMs) in targeted exons were related to significant better outcomes in stage II-III colorectal cancer (CRC). The detailed mutational profile of the entire POLE exonuclease domain, tumor mutation burden (TMB) and immune cell infiltration in POLE EDMs tumors, and the prognostic value of such mutations in stage II CRCs were largely unknown to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32859741
DOI: 10.1136/jitc-2020-000881
PMCID: PMC7454238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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