Article
HapMuC: somatic mutation calling using heterozygous germ line variants near candidate mutations.
Bioinformatics (Oxford, England) - 1 Dec 2014
Usuyama Naoto, Shiraishi Yuichi, Sato Yusuke, Kume Haruki, Homma Yukio, Ogawa Seishi, Miyano Satoru, Imoto Seiya
Abstract excerpt
MOTIVATION: Identifying somatic changes from tumor and matched normal sequences has become a standard approach in cancer research. More specifically, this requires accurate detection of somatic point mutations with low allele frequencies in impure and heterogeneous cancer samples. Although haplotype phasing information derived by using heterozygous germ line variants near candidate mutations would improve...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.