Article
Transcriptome sequencing from diverse human populations reveals differentiated regulatory architecture.
PLoS genetics - 1 Aug 2014
Martin Alicia R, Costa Helio A, Lappalainen Tuuli, Henn Brenna M, Kidd Jeffrey M, Yee Muh-Ching, Grubert Fabian, Cann Howard M, Snyder Michael, Montgomery Stephen B, Bustamante Carlos D
Abstract excerpt
Large-scale sequencing efforts have documented extensive genetic variation within the human genome. However, our understanding of the origins, global distribution, and functional consequences of this variation is far from complete. While regulatory variation influencing gene expression has been studied within a handful of populations, the breadth of transcriptome differences across diverse human populations has...
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