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Cancer Stem Cell Immunology: Key to Understanding Tumorigenesis and Tumor Immune Escape?

29 Jul 2014

Abstract excerpt

Cancer stem cell (CSC) biology and tumor immunology have shaped our understanding of tumorigenesis. However, we still do not fully understand why tumors can be contained but not eliminated by the immune system and whether rare CSCs are required for tumor propagation. Long latency or recurrence periods have been described for most tumors. Conceptually, this requires a subset of malignant cells which is capable of...

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PMID: 25120546
DOI: 10.3389/fimmu.2014.00360

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