Article
Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil.
BMC infectious diseases - 12 Aug 2014
Jarduli Luciana Ribeiro, Alves Hugo Vicentin, de Souza-Santana Fabiana Covolo, Marcos Elaine Valim Camarinha, Pereira Ana Carla, Dias-Baptista Ida Maria Foschiani, Fava Vinícius Medeiros, Mira Marcelo Távora, Moraes Milton Ozório, Virmond Marcos da Cunha Lopes, Visentainer Jeane Eliete Laguila
Abstract excerpt
BACKGROUND: The objective of this study was to investigate the association between KIR genes and the immunopathogenesis of leprosy. METHODS: The types of KIR and HLA genes were evaluated by PCR-SSOP-Luminex in 408 patients with leprosy and 413 healthy individuals. Statistical analysis was performed using the Chi-square or Fisher's exact test and stepwise multivariate analysis. RESULTS: There was a higher...
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