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Article

The exosome complex establishes a barricade to erythroid maturation

13 Aug 2014

Abstract excerpt

Complex genetic networks control hematopoietic stem cell differentiation into progenitors that give rise to billions of erythrocytes daily. Previously, we described a role for the master regulator of erythropoiesis, GATA-1, in inducing genes encoding components of the autophagy machinery. In this context, the Forkhead transcription factor, Foxo3, amplified GATA-1-mediated transcriptional activation. To determine...

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PMID: 25115889
DOI: 10.1182/blood-2014-04-571083

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