Article
A combined high CYP2D6-CYP2C19 metabolic capacity is associated with the severity of suicide attempt as measured by objective circumstances.
The pharmacogenomics journal - 1 Apr 2015
Peñas-Lledó E, Guillaume S, Naranjo M E G, Delgado A, Jaussent I, Blasco-Fontecilla H, Courtet P, LLerena A
Abstract excerpt
This study examined, for the first time, whether a high CYP2D6-CYP2C19 metabolic capacity combination increases the likelihood of suicidal intent severity in a large study cohort. Survivors of a suicide attempt (n=587; 86.8% women) were genotyped for CYP2C19 (*2, *17) and CYP2D6 (*3, *4, *4xN, *5, *6, *10, wtxN) genetic variation and evaluated with the Beck Suicide Intent Scale (SIS). Patients with a high...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.