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A one-year follow-up study of treatment-compliant suicide attempt survivors: relationship of CYP2D6-CYP2C19 and polypharmacy with suicide reattempts.

Translational psychiatry - 18 Oct 2022

Peñas-Lledó Eva M, Guillaume Sebastien, de Andrés Fernando, Cortés-Martínez Ana, Dubois Jonathan, Kahn Jean Pierre, Leboyer Marion, Olié Emilie, LLerena Adrián, Courtet Philippe

Abstract excerpt

This study of a cohort of 1-year treatment-compliant survivors of a suicide attempt examined for the first time whether a high CYP2D6-CYP2C19 metabolic capacity (pharmacogenes related to psychopathology, suicide, and attempt severity) and/or polypharmacy treatments predicted repeat suicide attempts, adjusting for sociodemographic and clinical factors as confounders. Of the 461 (63% women) consecutively...

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Identifiers

PMID: 36257936
DOI: 10.1038/s41398-022-02140-4
PMCID: PMC9579135

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