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Article

The nebulin repeat protein Lasp regulates I-band architecture and filament spacing in myofibrils

11 Aug 2014

Abstract excerpt

Mutations in nebulin, a giant muscle protein with 185 actin-binding nebulin repeats, are the major cause of nemaline myopathy in humans. Nebulin sets actin thin filament length in sarcomeres, potentially by stabilizing thin filaments in the I-band, where nebulin and thin filaments coalign. However, the precise role of nebulin in setting thin filament length and its other functions in regulating power output are...

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PMID: 25113030
DOI: 10.1083/jcb.201401094

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