Article
Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function.
Acta neuropathologica - 1 Sept 2015
Sztal Tamar E, Zhao Mo, Williams Caitlin, Oorschot Viola, Parslow Adam C, Giousoh Aminah, Yuen Michaela, Hall Thomas E, Costin Adam, Ramm Georg, Bird Phillip I, Busch-Nentwich Elisabeth M, Stemple Derek L, Currie Peter D, Cooper Sandra T, Laing Nigel G, Nowak Kristen J, Bryson-Richardson Robert J
Abstract excerpt
Nemaline myopathy is characterized by muscle weakness and the presence of rod-like (nemaline) bodies. The genetic etiology of nemaline myopathy is becoming increasingly understood with mutations in ten genes now known to cause the disease. Despite this, the mechanism by which skeletal muscle weakness occurs remains elusive, with previous studies showing no correlation between the frequency of nemaline bodies and...
Topics
- Actinin
- Actins
- Animals
- Animals, Genetically Modified
- Cytoplasm
- Disease Models, Animal
- Gene Knockdown Techniques
- Green Fluorescent Proteins
- Morpholinos