Article
Nebulin--a giant chameleon.
Advances in experimental medicine and biology - 1 Jan 2008
Pelin Katarina, Wallgren-Pettersson Carina
Abstract excerpt
Nebulin is an enormous protein of the muscle sarcomere. It is a determinant of thin filament length, Z-disk structure and fiber contractility. The nebulin gene contains four regions of alternative splicing, providing a wealth of different isoforms of the protein. The precise function of these numerous isoforms in various types of muscle tissue remains to be elucidated, as does their role in the maintenance of...
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