Article
Genetic screening in early-onset dementia patients with unclear phenotype: relevance for clinical diagnosis.
Neurobiology of aging - 1 Sept 2018
Perrone Federica, Cacace Rita, Van Mossevelde Sara, Van den Bossche Tobi, De Deyn Peter P, Cras Patrick, Engelborghs Sebastiaan, van der Zee Julie, Van Broeckhoven Christine
Abstract excerpt
In a prospective study of dementia in Flanders (Belgium), we observed a substantial fraction of early-onset dementia patients who did not fulfill the criteria for a specific dementia subtype, leaving the patients without a precise clinical diagnosis. We selected 211 of these patients for genetic testing of causal genes linked to neurodegenerative brain diseases. In this group, the onset or inclusion age was 59.9...
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