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Article

High frequency of mutations in four different disease genes in early-onset dementia.

Annals of the New York Academy of Sciences - 1 Jan 2000

Finckh U, Müller-Thomsen T, Mann U, Eggers C, Marksteiner J, Meins W, Binetti G, Alberici A, Sonderegger P, Hock C, Nitsch R M, Gal A

Abstract excerpt

Heterozygous mutations in the genes for amyloid precursor protein (APP), the presenilins (PS1, PS2), prion protein (PrP), neuroserpin, and tau are associated with early-onset dementia (EOD) with or without neurological signs in the early disease stage. To investigate the proportion of EOD without early neurological signs attributable to known genes we prospectively (i.e., ante mortem) screened these six genes for...

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Source

Identifiers

PMID: 11193137
DOI: 10.1111/j.1749-6632.2000.tb06910.x

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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