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Article

Frequency of mutations in the presenilin and amyloid precursor protein genes in early-onset Alzheimer disease in Spain.

Archives of neurology - 1 Nov 2002

Lleó Alberto, Blesa Rafael, Queralt Rosa, Ezquerra Mario, Molinuevo José L, Peña-Casanova Jordi, Rojo Ana, Oliva Rafael

Abstract excerpt

BACKGROUND: The relative contribution of mutations in the presenilin (PSEN) and amyloid precursor protein genes to autosomal dominant and other early-onset Alzheimer disease (AD) cases is not well established. OBJECTIVES: To clarify the respective contribution of the amyloid precursor protein and PSEN mutations to autosomal dominant AD and to determine its contribution to sporadic and familial nonautosomal...

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Identifiers

PMID: 12433263
DOI: 10.1001/archneur.59.11.1759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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