Article
Mutations in presenilin 1, presenilin 2 and amyloid precursor protein genes in patients with early-onset Alzheimer's disease in Poland.
Experimental neurology - 1 Dec 2003
Zekanowski Cezary, Styczyńska Maria, Pepłońska Beata, Gabryelewicz Tomasz, Religa Dorota, Ilkowski Jan, Kijanowska-Haładyna Beata, Kotapka-Minc Sławomira, Mikkelsen Sanne, Pfeffer Anna, Barczak Anna, Łuczywek Elzbieta, Wasiak Bogusław, Chodakowska-Zebrowska Małgorzata, Gustaw Katarzyna, Łaczkowski Jarosław, Sobów Tomasz, Kuźnicki Jacek, Barcikowska Maria
Abstract excerpt
Mutations in three causative genes have been identified in patients with an autosomal-dominant form of early-onset Alzheimer's disease (EOAD). To determine the spectrum of mutations in a group consisting of 40 Polish patients with clinically diagnosed familial EOAD and 1 patient with mild cognitive impairment (MCI) and family history of AD, we performed a screening for mutations in the presenilin 1 (PSEN1),...
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