IL-17A Alone Weakly Affects the Transcriptome of Intestinal Epithelial Cells but Strongly Modulates the TNF-α–induced Expression of Inflammatory Mediators and Inflammatory Bowel Disease Susceptibility Genes

Abstract excerpt

BACKGROUND: In contrast to anti-TNF-α antibodies, anti-IL-17A antibodies lacked clinical efficacy in a trial with patients suffering from Crohn's disease. We therefore analyzed how IL-17A modulates the inflammatory response elicited by TNF-α in intestinal epithelial cells (IEC). METHODS: Target mRNA levels in IEC and colonic biopsies were assessed by RNA microarray and quantitative real-time PCR. Signaling...

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