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Article

Activin A, B, and AB Increase Human Trophoblast Cell Invasion by Up-regulating N-Cadherin

8 Aug 2014

Abstract excerpt

CONTEXT: Inhibin β-subunits and activin receptors are expressed by human trophoblast cells. Although activin A has been shown to enhance human trophoblast cell invasion, whether two additional activin isoforms, activin B and AB, exert similar effects remains unknown. Moreover, whether the expression of mesenchymal adhesion molecule neural cadherin (N-cadherin) is essential for this proinvasive effect of activin...

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PMID: 25105734
DOI: 10.1210/jc.2014-2118

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Related research

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Research trail→

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Activin A, B, and AB Increase Human Trophoblast Cell Invasion by Up-regulating N-CadherinPMID 25105734Read ↗

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Bone morphogenetic protein 2 promotes human trophoblast cell invasion by upregulating N-cadherin via non-canonical SMAD2/3 signalingSemantic proximity Read ↗

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Autocrine-Paracrine Regulation of Human Trophoblast Invasiveness by Insulin-like Growth Factor (IGF)-II and IGF-Binding Protein (IGFBP)-1Semantic proximity Read ↗

The pro-inflammatory cytokines IFN-α and TNF-α inhibit organoid-derived extravillous trophoblast invasionSemantic proximity Read ↗

A disintegrin and metalloproteinase 12 (ADAM12) localizes to invasive trophoblast, promotes cell invasion and directs column outgrowth in early placental developmentSemantic proximity Read ↗

Extravillous Trophoblast-Associated ADAM12 Exerts Pro-Invasive Properties, Including Induction of Integrin Beta 1-Mediated Cellular Spreading1Semantic proximity Read ↗

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