Article
Differential Role of Smad2 and Smad3 in the Acquisition of an Endovascular Trophoblast-Like Phenotype and Preeclampsia.
Frontiers in endocrinology - 1 Jan 2020
Brkić Jelena, Dunk Caroline, Shan Yanan, O'Brien Jacob Anderson, Lye Phetcharawan, Qayyum Sheza, Yang Peifeng, Matthews Stephen G, Lye Stephen J, Peng Chun
Abstract excerpt
During placental development, cytotrophoblast progenitor cells differentiate into the syncytiotrophoblast and invasive extravillous trophoblasts (EVTs). Some EVTs further differentiate into endovascular trophoblasts (enEVTs) which exhibit endothelial-like properties. Abnormal placental development, including insufficient enEVT-mediated remodeling of the uterine spiral arteries, is thought to be a precipitating...
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