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Fibronectin mediates activin A-promoted human trophoblast migration and acquisition of endothelial-like phenotype

23 Jan 2024

Abstract excerpt

BACKGROUND: During human early placentation, a proportion of extravillous trophoblasts (EVTs) migrate to the maternal decidua, differentiating into endovascular EVTs to remodel spiral arteries and ensure the establishment of blood circulation at the maternal-fetal interface. Inadequate EVT migration and endovascular differentiation are closely associated with adverse pregnancy outcomes such as miscarriage....

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PMID: 38263146
DOI: 10.1186/s12964-023-01463-z

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