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Article

HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression

1 Apr 2021

Abstract excerpt

Abstract Background Hepatoma is a common malignancy of the liver. The abnormal high expression of alpha-fetoprotein (AFP) is intimately associated with hepatoma progress, but the mechanism of transcriptional regulation and singularly activation of AFP gene in hepatoma is not clear. Methods The expression of transcription factor HBP1 and AFP and clinical significance were further analyzed in hepatoma tissues from...

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PMID: 33794968
DOI: 10.1186/s13046-021-01881-2

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