Article
Combined effects of GSTO1 and SULT1A1 polymorphisms and cigarette smoking on urothelial carcinoma risk in a Taiwanese population.
Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Sept 2014
Tung Min-Che, Wang Yuan-Hung, Yeh Shauh-Der, Wu Chia-Chang, Chen Kuan-Chou, Huang Zhon-Min, Huang Ming-Te, Chiou Hung-Yi
Abstract excerpt
BACKGROUND/PURPOSE: Cigarette smoking is the main risk factor for urothelial carcinoma of the bladder (UCB). Glutathione S-transferase omega 1 (GSTO1) and sulfotransferase 1A1 (SULT1A1) have been reported to be associated with the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. The aim of the present study was to investigate the combined effects of polymorphisms in GSTO1 and SULT1A1...
Topics
- Aged
- Arylsulfotransferase
- Carcinoma, Transitional Cell
- DNA, Neoplasm
- Female
- Genotype
- Glutathione Transferase
- Humans
- Male
- Middle Aged
- Odds Ratio
- Polymerase Chain Reaction
- Polymorphism, Genetic