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Article

Experimental sheep BSE prions generate the vCJD phenotype when serially passaged in transgenic mice expressing human prion protein.

Journal of the neurological sciences - 15 Mar 2018

Joiner Susan, Asante Emmanuel A, Linehan Jacqueline M, Brock Lara, Brandner Sebastian, Bellworthy Susan J, Simmons Marion M, Hope James, Collinge John, Wadsworth Jonathan D F

Abstract excerpt

The epizootic prion disease of cattle, bovine spongiform encephalopathy (BSE), causes variant Creutzfeldt-Jakob disease (vCJD) in humans following dietary exposure. While it is assumed that all cases of vCJD attributed to a dietary aetiology are related to cattle BSE, sheep and goats are susceptible to experimental oral challenge with cattle BSE prions and farmed animals in the UK were undoubtedly exposed to...

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Identifiers

PMID: 29406965
DOI: 10.1016/j.jns.2017.12.038
PMCID: PMC5946165

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