Article
Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women.
Mucosal immunology - 1 Mar 2015
Sacha C R, Vandergrift N, Jeffries T L, McGuire E, Fouda G G, Liebl B, Marshall D J, Gurley T C, Stiegel L, Whitesides J F, Friedman J, Badiabo A, Foulger A, Yates N L, Tomaras G D, Kepler T B, Liao H X, Haynes B F, Moody M A, Permar S R
Abstract excerpt
A successful HIV-1 vaccine must elicit immune responses that impede mucosal virus transmission, though functional roles of protective HIV-1 Envelope (Env)-specific mucosal antibodies remain unclear. Colostrum is a rich source of readily accessible mucosal B cells that may help define the mucosal antibody response contributing to prevention of postnatal HIV-1 transmission. To examine the HIV-1 Env-specific...
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