Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants.

doi:10.1128/mBio.00176-20

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Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants.

mBio - 10 Mar 2020

Martinez David R, Tu Joshua J, Kumar Amit, Mangold Jesse F, Mangan Riley J, Goswami Ria, Giorgi Elena E, Chen Juilin, Mengual Michael, Douglas Ayooluwa O, Heimsath Holly, Saunders Kevin O, Nicely Nathan I, Eudailey Joshua, Hernandez Giovanna, Morgan-Asiedu Papa Kwadwo, Wiehe Kevin, Haynes Barton F, Moody M Anthony, LaBranche Celia, Montefiori David C, Gao Feng, Permar Sallie R

Abstract excerpt

Each year, >180,000 infants become infected via mother-to-child transmission (MTCT) of HIV despite the availability of effective maternal antiretroviral treatments, underlining the need for a maternal HIV vaccine. We characterized 224 maternal HIV envelope (Env)-specific IgG monoclonal antibodies (MAbs) from seven nontransmitting and transmitting HIV-infected U.S. and Malawian mothers and examined their...

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PMID: 32156815
DOI: 10.1128/mBio.00176-20
PMCID: PMC7064758

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Source receipt: pubmed, retrieved 7 Sept 2026.

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