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Article

Role of loop-loop interactions in coordinating motions and enzymatic function in triosephosphate isomerase.

Biochemistry - 2 Jun 2009

Wang Yan, Berlow Rebecca B, Loria J Patrick

Abstract excerpt

The enzyme triosephosphate isomerase (TIM) has been used as a model system for understanding the relationship between protein sequence, structure, and biological function. The sequence of the active site loop (loop 6) in TIM is directly correlated with a conserved motif in loop 7. Replacement of loop 7 of chicken TIM with the corresponding loop 7 sequence from an archaeal homologue caused a 10(2)-fold loss in...

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PMID: 19348462
DOI: 10.1021/bi9002887
PMCID: PMC2713366

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Role of loop-loop interactions in coordinating motions and enzymatic function in triosephosphate isomerase.PMID 19348462Read ↗

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