Article
Disruption of the gaa Gene in Zebrafish Fails to Generate the Phenotype of Classical Pompe Disease.
DNA and cell biology - 1 Jan 2017
Wu Jing, Yang Yi, Sun Chengjun, Sun Shaoyang, Li Qiang, Yao Yuxiao, Fei Fei, Lu Lingeng, Chang Zhuo, Zhang Wenting, Wang Xu, Luo Feihong
Abstract excerpt
The underlying pathogenic lesions of glycogen storage disease type II (GSD II) and the diversity of this disease among different species are still under exploration. Thus, we created an acid alpha-glucosidase (gaa) gene-mutated zebrafish model of GSD II and examined the sequential pathogenic changes. gaa mRNA and protein expression, enzymatic activity, and lysosomal glycogen accumulation were assessed, and the...
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