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Article

Active CREB1 Promotes a Malignant TGFβ2 Autocrine Loop in Glioblastoma

1 Aug 2014

Abstract excerpt

UNLABELLED: In advanced cancer, including glioblastoma, the TGFβ pathway acts as an oncogenic factor. Some tumors exhibit aberrantly high TGFβ activity, and the mechanisms underlying this phenomenon are not well understood. We have observed that TGFβ can induce TGFβ2, generating an autocrine loop leading to aberrantly high levels of TGFβ2. We identified cAMP-responsive element-binding protein 1 (CREB1) as the...

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Share to Glioma Diagnosis and Treatment
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PMID: 25084773
DOI: 10.1158/2159-8290.cd-14-0275

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