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Article

IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity.

The Journal of experimental medicine - 14 Apr 2008

Forbes Elizabeth E, Groschwitz Katherine, Abonia J Pablo, Brandt Eric B, Cohen Elizabeth, Blanchard Carine, Ahrens Richard, Seidu Luqman, McKenzie Andrew, Strait Richard, Finkelman Fred D, Foster Paul S, Matthaei Klaus I, Rothenberg Marc E, Hogan Simon P

Abstract excerpt

Previous mouse and clinical studies demonstrate a link between Th2 intestinal inflammation and induction of the effector phase of food allergy. However, the mechanism by which sensitization and mast cell responses occurs is largely unknown. We demonstrate that interleukin (IL)-9 has an important role in this process. IL-9-deficient mice fail to develop experimental oral antigen-induced intestinal anaphylaxis, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18378796
DOI: 10.1084/jem.20071046
PMCID: PMC2292227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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