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IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut

1 May 2018

Abstract excerpt

Candida albicans is implicated in intestinal diseases. Identifying host signatures that discriminate between the pathogenic versus commensal nature of this human commensal is clinically relevant. In the present study, we identify IL-9 and mast cells (MCs) as key players of Candida commensalism and pathogenicity. By inducing TGF-β in stromal MCs, IL-9 pivotally contributes to mucosal immune tolerance via the...

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PMID: 29742432
DOI: 10.1016/j.celrep.2018.04.034

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