Article
Novel role of estrogen receptor-α on regulating chondrocyte phenotype and response to mechanical loading.
Osteoarthritis and cartilage - 1 Feb 2022
Wang N, Zhang X, Rothrauff B B, Fritch M R, Chang A, He Y, Yeung M, Liu S, Lipa K E, Lei G, Alexander P G, Lin H
Abstract excerpt
OBJECTIVE: In knee cartilage from patients with osteoarthritis (OA), both preserved cartilage and damaged cartilage are observed. In this study, we aim to compare preserved with damaged cartilage to identify the molecule(s) that may be responsible for the mechanical loading-induced differences within cartilage degradation. METHODS: Preserved and damaged cartilage were harvested from the same OA knee joint. RNA...
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