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Toxicology‐based cancer causation analysis of CoCr‐containing hip implants: a quantitative assessment of genotoxicity and tumorigenicity studies

30 Jul 2014

Abstract excerpt

In this paper, quantitative methods were used to evaluate the weight of evidence regarding a causative relationship between cobalt-chromium (CoCr)-containing hip implants and increased cancer risk. We reviewed approximately 80 published papers and identified no-observed-adverse-effect level (NOAEL) and/or lowest-observed-adverse-effect level (LOAEL) values for specific endpoints of interest: genotoxic effects...

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PMID: 25080401
DOI: 10.1002/jat.3039

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